Linda Shimizu

Dr Shimizu at the International Symposium for Macrocyclic and Supramolecular Chemistry, Kyoto, Japan, 2025

Professor of Chemistry

University of South Carolina

Department of Chemistry and Biochemistry

Columbia, SC 29208

RESEARCH INTERESTS

  • Organic, Supramolecular Chemistry, Non Equilibrium Systems, Nanomaterials, Bioorganic, Organic Photochemistry, Crystal Engineering

PROFESSIONAL EXPERIENCE

  • Professor, Chemistry and Biochemistry, University of South Carolina, Columbia SC, 2016 – present.
  • Fulbright US Scholar, University of Vienna Visiting Professor of Science, March 1, 2018 – June 30, 2018.
  • Associate Professor, Chemistry and Biochemistry, University of South Carolina, Columbia SC, 2011 – 2015.
  • Visiting Professor, Center for Nanosystems Chemistry and the Institute of Organic Chemistry, University of Würzburg, Germany, Summer 2015.
  • Assistant Professor, Chemistry and Biochemistry, University of South Carolina, Columbia SC, 2005 – 2011.
  • Research Assistant Professor (part-time), University of South Carolina, Columbia SC, June 1998-Jan 1999, 2000-2001, 2003-2005.
  • Consultant Abt Associates Inc. 2003 –2004

 EDUCATION

  • NIH Post-doctoral Fellow, Massachusetts Institute of Technology, Cambridge, MA  1997- 1998,
  • Ph.D. in Organic Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 1997
  • Dissertation: “Synthesis and Conformation of Peptides:  I. Stability of Short Templated a-Helical Peptides.  II. New Templates for Intramolecular Acyl Transfer.”
  • BA in Chemistry and German Language and Literature, Magna Cum Laude, Wellesley College, MA, 1990.

HONORS AND AWARDS

  • 2025 ACS Fellow
  • Outstanding South Carolina Chemist, South Carolina Section of the ACS, 2024
  • SC Governor’s Award for Scientific Awareness, 2021
  • Fulbright U.S. Scholar grant, 2017-2018
  • Michael J. Mungo Undergraduate Teaching Award, 2016
  • Editorial Board, Journal of Photochemistry and Photobiology A: Chemistry, 2014 – present
  • Editorial Board, Supramolecular Chemistry, 2014 – present
  • SC ACS Outreach Volunteers of the Year, 2014
  • ACS Women Chemists Committee 2013 Rising Star Award
  • USC Breakthrough Rising Star, 2011.

PUBLICATIONS / BOOK CHAPTERS    

  1. Gbadamosi, Fahidat A.; Islam, Md Faizul; Shaker, Abdulla E.; Wijesekera, Gamage Isuri P.; Smith, Mark D.; Winfredd, J. S. Raaj Vellore; Wetthasinghe, Shehani T.; Garashchuk, Sophya; Greytak, Andrew B.; Shimizu, Linda S.* Charge-transfer driven electrical conductivity in single crystals of assembled triphenylamine bis-urea macrocycles. J. Phys. Chem. C 2025, 129, 15922-15931. https://pubs.acs.org/doi/full/10.1021/acs.jpcc.5c04522
  2. Wijesekera, Gamage Isuri P.; Rushton, Isabella G.; Samant, Vaibhavi A.; Gbadamosi, Fahidat A.; Islam, Md Faizul; Smith, Mark D.; Wetthasinghe, Shehani T.; Garashchuk, Sophya; Shimizu, Linda S. Kinetic Control and Trapping in the Supramolecular Polymerization of m-Terphenyl Bis-Urea Macrocycles. Chem-Eur. J. 2025 31, e202404552. https://doi.org/10.1002/chem.202404552. 
  3. Islam, Md. Faizul; Wijesekera, Gamage Isuri P.; Sindt, Ammon J.; Smith, Mark D.; Shimizu, Linda S.* Examination of Photoinduced Radicals in Two Crystal Forms of Triphenylamine Bis-Urea Macrocycles. CrystEngComm. 2024 DOI: 10.1039/D4CE00839A.
  4. Wijesekera, Gamage Isuri P.; Gbadamosi, Fahidat A.; Hossain, Muhammad Saddam; Patra, Abhilash; Sutton, Christopher A.*; Shimizu Linda S.* Understanding the Key Factors for Photoinduced Radical Generation in Crystalline Triphenylamines Using Experiment and Machine Learning.  J. Phys. Chem. C 2024, https://pubs.acs.org/doi/10.1021/acs.jpcc.4c03579.
  5. Prakash, Rahul; Esmaeili, Mohsen; Gbadamosi, Fahidat, Pellechia, Perry J.; Sadati, Monirosadat; Shimizu, Linda S.* Supramolecular Gelation of Triphenylamine Bis-Urea Macrocycles in Toluene.  Macromolecules 2024, 57, 1312-1318.  https://pubs.acs.org/doi/10.1021/acs.macromol.3c02402.
  6. Rubert, Llorenc; Islam, Md Faizul; Greytak, Andrew B.; Prakash, Rahul; Smith, Mark, D.; Gomila, Rosa Maria; Frontera, Antonio; Shimizu, Linda S.*; Soberats, Bartolome* Two-Dimensional Supramolecular Polymerization of a Bis-Urea Macrocycle into a Brick-Like Hydrogen-Bonded Network. Angew. Chem. Int. Ed.  2023, 62, e202312223. https://onlinelibrary.wiley.com/doi/abs/10.1002/ange.202312223 
  7. Prakash, Rahul; Islam, Md Faizul; Kothalawala, Rajeen Madawa; Hossain, Mohammad Saddam; Smith, Mark D.; Shimizu, Linda S.* Cooperative Supramolecular Polymerization of Triphenylamine bis-Urea Macrocycles. Chem-Eur. J. 2023, 29, e202300698. https://doi.org/10.1002/chem.202300698
  8. Selvanesan, Benson Chellakkan; Varghese, Sheelu; Andrys, Justyna; Hernandez, Ricardo Arriaza; Prakash, Rahul; Tiwari, Purushottam; Hupalo, Daniel; Gusev, Yuriy; Patel, Meghja Nitin; Contente, Sara; Sanda, Miloslav; Uren, Aykut; Wilkerson, Matthew D.; Dalgard, Clifton Lee; Shimizu, Linda S.; Chruszcz, Maksymilian; Borowski, Tomasz; Upadhyay, Geeta* LY6K signaling to Aurora Kinase promotes advancement of the cell cycle and the growth of cancer cells, which is inhibited by LY6K-NSC243928 interaction. Cancer Lett. 2023, (* from USUHS) 10.1016/j.canlet.2023.216094
  9. Busschaert, Nathalie*; Garcia-Lopez, Victor; Ke, Chenfeng; McGuirk, C. Michael; Shimizu, Linda S.; Gerthoffer, Margaret C.; Bhattacharjee, Nabarupa  NASC: bringing together Supramolecular chemists from across North America, Supramol. Chem. 2023, 10.1080/10610278.2023.2178724
  10. Prakash, Rahul; Goodlett, Dustin W.; Gbadamosi, Fahidat; Hernandez, Ricardo A.; Chruszcz, Maksymilian; Borowski, Tomasz; Shimizu, Linda S.; Upadhyay, Geeta* Development of fluorophore labeled or biotinylated anticancer small molecule NSC243928. Bioorg. Med. Chem. 2023, 79, 117171. https://doi.org/10.1016/j.bmc.2023.117171  *From Uniformed Services University of Health Sciences
  11. Islam, Md. Faizul; Adame-Ramirez, Emely; Williams, Eric; Kittikhunnatham, Preecha; Wijesekera, Andrew; Zhang, Siteng; Ge, Ting; Stefik, Morgan; Smith, Mark, D.; Pellechia, Perry J.; Greytak, Andrew B.; Shimizu, Linda S.* Inclusion polymerization of pyrrole and ethylenedioxythiophene in assembled triphenylamine bis-urea macrocycles, Macromolecules, 2022, 55, 11013-11022. https://doi.org/10.1021/acs.macromol.2c02042
  12. Hossain, M. S.; Ahmed, F., Karakalos, S. G.; Smith, Mark, D.; Pant, N.; Garashchuk, S.; Greytak, A. B.; Docampo, P.; Shimizu, L. S.* Structure Property Investigations in Urea Tethered Iodinated Triphenylamines.
    Phys. Chem. Chem. Phys. 2022, 24, 18729-18737. https://doi.org/10.1039/D2CP01856J
  13. Oluwatoba, D. S.; Islam, M. F.; Som, B.; Sindt, A. J.; Smith, M. D.; Shimizu, L. S.; Do, T. D.* Evaluating the Effects of Metal Adduction and Charge Isomerism on Ion-Mobility Measurements using m-Xylene Macrocycles as Models. J. Am. Soc. Mass Spec. 2022, 33, 5, 840-850. https://doi.org/10.1021/jasms.2c00033.
  14. Helmers, I.; Hossain, M. S.; Bäumer, Nils; Wesarg, P.; Soberats, B.; Shimizu, L. S.*; Fernández, G.* Anti-cooperative Self-Assembly with Maintained Emission Regulated by Conformational and Steric Effects. Angew. Chem. Int. Ed. 2022,134, e202200390. DOI:10.1002/anie.202200390. Angew. Chem. 2022, 134, e202200390, DOI: 10.1002/ange.202200390.
  15. Daneshian, L.; Renggli, I.; Hanaway, R.; Offermann, L. R.; Schlacter, C. R.; Hernandez, R. A.; Henry, S.; Prakash, R.; Wybouw, N.; Dermauw, W.; Shimizu, L. S.; Van Leeuwen, T.; Makris, R.; Grbic. V.; Gribic, M.; Chruszcz, M.* Structural and Functional Characterization of Beta-Cyanoalanine Synthase from Tetranychus urticae. Insect Biochem. Molec. 2022, 142, 103722. https://doi.org/10.1016/j.ibmb.2022.103722
  16. Goodlett, R. L.; Sindt, A. J.; Islam, Md F.; Smith, M. D.; Shimizu, L. S.* Selective loading of xylene constitutional isomers in a self-assembled triphenylamine bis-urea macrocycle host. Cryst. Growth Des. 2022, 22, 1017-1023. DOI:10.1021/acs.cgd.1c00846.
  17. Islam, Md. F.; Sindt, A. J.; Hossain, M. S.; Ayare, P. J.; Smith, M. D.; Vannucci, A. K.; Garashchuk, S.; Shimizu, L. S.* Assembled triphenylamine bis-urea macrocycles: Exploring photodriven electron transfer from host to guests. Phys. Chem. Chem. Phys. 2021, 23, 23952-23960. DOI:10.1039/D1CP03000K.
  18. Hossain, M. S.; Sindt, A. J.; Goodlett, R. L.; Shields, D.; O’Connor, C. J.; Antevska, A.; Krakalos, S. G.; Smith, M. D.; Garashchuk, S.; Do, T. D.; Gudmundsdottir, A.; Shimizu, L. S.* Effects of self-assembly on the photogeneration of radical cations in halogenated triphenylamines. J. Phys. Chem. C 2021, 125, 19991-20002. DOI:10.1021/acs.jpcc.1c04933
  19. Som, B.; Smith, M. D.; Shimizu, L. S.* Multi-dimensional copper(I) and silver(I) coordination polymers assembled with a pyridyl bis-urea macrocyclic ligand. Polyhedron 2021, 201, 115170. DOI:10.1016/j.poly.2021.115170.
  20. Goodlett, R. L.; Sindt, A. J.; Hossain, M. S.; Merugu, R.; Smith, M. D.; Garashchuk, S.; Gudmundsdottir, A. D.; Shimizu, L. S.* From incident light to persistent and regenerable radicals of urea-assembled benzophenone frameworks: A structural investigation. J. Phys. Chem. A 2021, 126, 1336-1344. DOI:10.1021/acs.jpca.0c08953.
  21. Pote, S.; Kachhap, S.; Mank, N. J.; Daneshian, L.; Klapper, V.; Pye, S.; Arnett, A. K.; Shimizu, L. S.; Borowski, T.; Chruszcz, M.* Comparative structural and mechanistic studies of 4-hydroxy-tetrahydrodipicolinate reductases from Mycobacterium tuberculosis and Vibrio vulnificus. Biochimica et Biophysica Acta – General subjects 2021, 1865, 129750, DOI:1016/j.bbagen.2020.129750.
  22. Link, B. A.; Sindt, A. J.; Shimizu, L. S.; Do, T. D.* Selective host-guest chemistry: Self-assembly and conformational preferences of m-xylene macrocycles probed by ion-mobility mass spectrometry, Phy. Chem. Chem. Phys, 2020, 22, 9290-9300. *From University of Tennessee, Knoxville.  DOI:10.1039/C9CP06938K.
  23. Benti, S.; Tiwari, P. B.; Goodlett, D. W.; Daneshian, L.; Kern, G. B.; Smith, M. D.; Uren, A.; Chruszcz, M.; Shimizu, L. S.; Upadhyay, G.* Small molecule binds with Lymphocyte antigen 6K to induce cancer cell death. Cancers 2020, 12, 509- DOI:3390/cancers12020509. *From Uniformed Services University of Health Sciences
  24. Sindt, A. J.; DeHaven, B. A.; Goodlett, R. L.; Hartel, J. O.; Ayare, P. J.; Du, Y.; Smith, M. D.; Brugh, A. M.; Forbes, M. D. E.; Bowers, C. R.; Vannucci, A. K.; Shimizu, L. S.* Guest inclusion modulates concentration and persistence of photogenerated radicals in assembled triphenylamine macrocycles. J. Am. Chem. Soc. 2020, 142, 502-511. DOI: 10.1021/jacs.9b11518
  25. DeHaven, B. A.; Chen, A. L.; Shimizu, E. A.; Smith, M. D.; Shimizu, L. S.* Interplay between hydrogen and halogen bonding in co-crystals of dipyridylmethyl oxalamides and tetrafluorodiidodbenzenes. Cryst. Growth Des. 2019, 19, 5776-5783, doi: 10.1021/acs.cgd.9b00796.
  26. DeHaven, B. A.; Liberatore, H. K.; Greer, A.; Richardson, S. D.; Shimizu, L. S.* Probing the formation of reactive oxygen species by a porous self-assembled benzophenone bis-urea host. ACS Omega 2019, 4, 8290-8298, doi: 10.1021/acsomega.9b00831.
  27. Sindt, A. J.; Smith, M. D.; Berens, S.; Vasenkov, S.; Bowers, C. R.; Shimizu, L. S.* Single-crystal-to-single-crystal guest exchange in columnar assembled bromotriphenylamine bis-urea macrocycles. Chem. Commun. 2019, 55, 5619-5622, doi: 10.1039/C9CC01725A.
  28. Sindt, A. J.; DeHaven, B. A.; McEachern, D. F.; Dissanayake, M. M.; Smith, M. D.; Vannucci, A. K.; Shimizu, L. S.* UV-irradiation of self-assembled triphenylamines affords persistent and regenerable radicals. Chem Sci. 2019, 10, 2670-2677 doi: 10.1039/C8SC04607G.
  29. DeHaven, B. A.; Goodlett, R. L.; Sindt, A. J.; Noll, N.; DeVetta, M.; Smith, M. D.; Martina, C. R.; González, L.; Shimizu, L. S.* Enhancing the stability of photogenerated benzophenone triplet radical pairs through supramolecular assembly. J. Am. Chem. Soc.2018, 140, 13064-13070, doi 10/1021/jacs.8b08501.
  30. Sindt, A. J.; Smith, M. D.; Pellechia, P. J.; Shimizu, L. S.* Thioureas and Squaramides: A Comparison with Ureas as Assembly Directing Motifs for m-xylene macrocycles. Cryst. Growth Des. 2018, 18, 1602-1612, doi:10.1021/acs.cgd.7b01558.
  31. Som, B.; Shue, J.; Smith, M. D.; Shimizu, L. S.* Temperature induced polymorphism of salt co-crystal solvates from a Pyridyl Bis-urea Macrocycle with Naphthalene-1,5-disulfonic acid.J. Chem. Crystallogr., 2018, C74, 75-81, doi: 10.1107/S2053229617017600.
  32. DeHaven, B. A.; Chen, A. L.; Shimizu, E. A.; Salpage, S. R.; Smith, M. D.; Shimizu, L. S.* Synergistic Effects of Hydrogen and Halogen Bonding in Co-Crystals of Dipyridyl Ureas and Diiodotetrafluoro-benzenes. Supramol. Chem. 2018, 30, 315-327, doi: 10.1080/10610278.2017.136480.
  33. Kittikhunnatham, P.; Som, B.; Rassolov, V.; Stolte, M.; Würthner, F.; Shimizu, L. S. Greytak, A. B.* Fluorescence Polarization Measurements to Probe Alignment of a Bithiophene Dye in 1D channels of Self-Assembled Bis-Urea Macrocycle Crystals. J. Phys. Chem. C. 2017, 121, 18102-18109. doi: 10.1021/acs.jpcc.7b07136.
  34. DeHaven, B. A.; Tokarski, J. T.; Korous, A. A.; Mentink-Vigier, F.; Makris, T. M.; Brugh, A. M.; Forbes, M. D. E.; van Tol, J.; Bowers, C. R.; Shimizu, L. S.* Endogenous radicals of self-assembled benzophenone bis-urea macrocycles: characterization and application as a polarizing agent for solid-state DNP MAS NMR spectroscopy. Chem-Eur J. 2017, 23, 8315-8319, doi: 1002/chem.201701705.
  35. Som, B.; Salpage, S. R.; Son, J.-O.; Gu, B.; Karakalos, S. G.; Smith, M. D.; Shimizu, L. S.* Pillars of assembled pyridyl bis-urea macrocycles: A robust synthon to organize diiodotetrafluorobenzenes. CrystEngComm, 2017, 19, 484-491, doi 1039/C6CE02392D.
  36. Salpage, S. R.; Xu, Y.; Som, B.; Sindt, A. J.; Smith, M. D.; Shimizu, L. S.* Pyridyl-phenylethynylene Bis-Urea Macrocycles: Self-Assembly and Utility as a Nanoreactor for the Selective Photoreaction of Isoprene. RSC Advances 2016, 6, 98350-98355, doi: 1039/C6RA18681E.
  37. Salpage, S. R.; Paul, A.; Som, B.; Banerjee, T.; Hanson, K.; Smith, M. D.; Vannucci, A. K.; Shimizu, L. S.* Structure, electrochemistry and photophysical properties of an exo diruthenium complex using a macrocyclic bridging ligand and its application as a photosensitizer. Dalton Trans. 2016, 45, 9601-9607, doi: 1039/C6DT01377E.
  38. Salpage, S. R.; Smith, M. D.; Shimizu, L. S.* Crystal Structures and Hirshfeld Surface Analyses of 6-Substituted Chromones. J. Chem. Crystallogr. 2016, 46, 170-180, doi: 10.1007/s10870-016-0642-2.
  39. Salpage, S. R.; Donevant, L. S.; Smith, M. D.; Bick, A.; Shimizu, L. S.* Modulating the Reactivity of Chromone and Its Derivatives through Encapsulation in a Self-Assembled Phenylethynylene Bis-Urea Host. J. Photochem. Photobio. A 2016, 315, 14-24, doi: 10.1016/j.jphotochem.2015.09.003.
  40. Bowers, C. R.*; Dvoyahshin, M.; Salpage, S. R.; Akel, C.; Bhase, H.; Geer, M. F.; Shimizu, L. S.* Squeezing Xenon into Phenylether bis-Urea Nanochannels. Can. J. Chem. 2015, 93, 1031-1034, doi: dx.doi.org/10.1139/cjc-2015-0152.
  41. Bowers, C. R.*; Dvoyahshin, M.; Salpage, S. R.; Akel, C.; Bhase, H.; Geer, M. F.; Shimizu, L. S.* Crystalline bis-Urea Nanochannel Architectures Tailored for Single-File Diffusion Studies. ACS Nano 2015, 9, 6343-6353.
  42. Dawn, S.; Salpage, S. R.; Koscher, B. A.; Wibowo, A. C.; Pellechia, P. J.; Shimizu, L. S.* Applications of a bis-urea phenylethynylene self-assembled nanoreactor for [2+2] photodimerizations. J. Phys. Chem. A. 2014, 118, 10563-10574.
  43. Shimizu, L. S.*; Salpage, S. R.; Korous A. F. Functional Materials from Self-Assembled bis-Urea Macrocycles. Acc. Chem. Res. 2014, 47, 2116-2127.
  44. Xu, W. L.; Smith, M. D.; Krause, J. A.; Greytak, A. B.; Ma, S.; Read, C. M.; Shimizu, L. S.* Single Crystal to Single Crystal Polymerization of a Self-Assembled Diacetylene Macrocycle Affords Columnar Polydiacetylenes. Cryst. Grow. Des. 2014, 14, 993-1002.
  45. Xu, Y.; Xu, W. L.; Smith, M. D.; Shimizu, L. S.* Self-assembly and Ring-opening Metathesis Polymerization of a Bifunctional Carbonate Stilbene Macrocycle. RSC Advances, 2014, 4, 1675-1682.
  46. Geer, M. F.; Mazzuca, J.; Smith, M. D.; Shimizu, L. S.* Strong, short halogen bonds in co-crystals of pyridyl bis-urea macrocycles with iodo-perfluorocarbons. Cryst. Eng. Comm. 2013, 15, 9923-9929.
  47. Caricato, M.; Leza, N.; Roy, K.; Dondi, D.; Gattuso, G.; Shimizu, L. S.; Vander Griend D. A.; Pasini, D.* A Chiroptical Probe for Sensing Metal Ions in Physiological Conditions. J. Org. Chem. 2013, 6078-6083.
  48. Geer, M. F.; Walla, M. D.; Solntsev, K. M.; Strassert, C. A.; Shimizu, L. S.* Self-assembled benzophenone bis-urea macrocycles facilitate selective oxidations by singlet oxygen. J. Org. Chem. 2013, 78, 5568-5578.
  49. Roy, K.; Wibowo, A. C.; Pellechia, P. J.; Ma, S.; Geer, M. F.; Shimizu, L. S.* Absorption of hydrogen bond donors by pyridyl bis-urea crystals. Chem. Mater. 2012, 24, 4773-4781.
  50. Dawn, S.; Salpage, S. R.; Smith, M. D.; Sharma, S. K.; Shimizu, L. S.* A trinuclear silver coordination polymer from a bipyridine bis-urea macrocyclic ligand and silver triflate. Chem. Commun. 2012, 15, 88-92.
  51. Geer, M. F.; Shimizu, L. S.* “Self-Assembly and Self-Organization” Chapter in Volume 1: Concepts in Supramolecular Chemistry From Molecules to Nanomaterials Series Editors: Philip A. Gale, Jonathan, W. Steed, John Wiley & Sons, Ltd. United Kingdom, 2012, 1, 167-180.
  52. Xu, Y.; Shimizu, L. S.* “Urea Capsules” In The Encyclopedia of Supramolecular Chemistry; Atwood, J. L.; Steed, J. W.; Wallace, K. J., Ed.; Taylor and Francis, CDC Press, 2012, doi 1081/E-ESMC-120048280.
  53. Dawn, S.; Dewal, M. B.; Sobransingh, D.; Paderes, M. C.; Wibowo, A. C.; Krause, J. A.; Smith, M. D.; Pellechia, P. J.; Shimizu, L. S.* Porous crystals from self-assembled phenylethynylene bis-urea macrocycles facilitate the selective photodimerization of coumarin. J. Am. Chem. Soc. 2011, 133, 7025-7032.
  54. Roy, K.; Smith, M. D.; Shimizu, L. S.* 1D coordination network formed by a cadmium based pyridyl urea helical monomer. Inorg. Chim. Acta 2011, 376, 598-604.
  55. Geer, M. F.; Smith, M. D.; Shimizu, L. S.* A bis-urea naphthalene macrocycle displaying two crystal structures with parallel ureas. Cryst. Eng. Comm. 2011, 13, 3665-3669.
  56. Roy, K.; Wang, C.; Smith, M. D.; Dewal, M. B.; Wibowo, A. C.; Brown, J. C.; Ma, S.; Shimizu, L. S.* Guest induced transformations of assembled pyridyl bis-urea Chem. Commun. 2011, 47, 277-279.
  57. Roy, K.; Wang, C.; Smith, M. D.; Pellechia, P. J.; Shimizu, L. S.* Alkali metal ions as probes of structure and recognition properties of macrocyclic pyridyl urea hosts. J.Org. Chem. 2010, 75, 5453-5460, Featured Article.
  58. Xu, Y.; Smith, M. D.; Geer, M. F.; Pellechia, P. J.; Brown, J. C.; Wibowo, A. C.; Shimizu, L. S.* Thermal reaction of a columnar assembled diacetylene macrocycle. J. Am. Chem. Soc. 2010, 132, 5334-5335. Highlighted by Synfacts.
  59. Tian, L.; Wang, C.; Dawn, S.; Smith, M. D.; Krause, J. A.; Shimizu, L. S.* Macrocycles with switchable exo/endo metal binding sites. J. Am. Chem. Soc. 2009, 131, 17620-17629.
  60. Yang, J.; Dewal, M. B.; Sobransingh, D.; Xu, Y.; Smith, M. D.; Shimizu, L. S.* An examination of the structural features that favor the columnar self-assembly of bis-urea macrocycles. J. Org. Chem. 2009, 74, 102-110.
  61. Xu, Y.; Smith, M. D.; Krause, J.; Shimizu, L. S.* Control of the intramolecular [2+2] photocycloaddition of a bis-stilbene macrocycle. J. Org. Chem. 2009, 74, 4874-4877.
  62. Dewal, M. B.; Xu, Y.; Yang, J.; Mohammed, F.; Smith, M. D.; Shimizu, L. S.* Manipulating the cavity of a porous material changes the photoreactivity of included guests. Chem. Commun. 2008, 3909-3911. Highlighted by Nature Chem., July 11, 2008, doi:10.1038/nchem.36.
  63. Yang, J.; Dewal, M. B.; Profeta, S.; Smith, M. D.; Li, Y.; Shimizu, L. S.* Origins of selectivity for the [2+2] cycloaddition of alpha, beta-unsaturated ketones within a porous self-assembled organic framework. J. Am. Chem. Soc. 2008, 130, 612-621.
  64. Sobransingh, D.; Dewal, M. B.; Hiller, J.; Smith, M. D.; Shimizu, L. S.* Inclusion of electrochemically active guests by novel oxacalixarene hosts. New. J. Chem. 2008, 32, 24-27.
  65. Shimizu, L. S.* Perspectives in main-chain hydrogen bonded supramolecular polymers. Polymers International 2007, 56, 444-452.
  66. Dewal, M. B.; Lufaso, M. W.; Hughes, A. D.; Samuel, S. A.; Pellechia, P.; Shimizu L. S.* Absorption properties of a porous organic crystalline apohost formed by a self-assembled bis-urea macrocycle. Chem.  Mater. 2006, 18, 4855-4864.
  67. Yang, J.; Dewal, M. B.; Shimizu, L. S.* Self-assembling bis-urea macrocycles used as an organic zeolite for a highly stereoselective photodimerization of 2-cyclohexenone. J. Am. Chem. Soc. 2006, 128, 8122-8123.
  68. Shimizu, L. S.*; Smith, M. D.; Hughes, A. D.; Samuel, S.; Ciurtin-Smith, D. Assembled tubular structures from bis-urea macrocycles. Supramolecular Chem. 2005, 17, 27-30.
  69. Ricks, H. L.; Shimizu, L. S.; Smith, M. D.; Bunz, U. H. F.; Shimizu, K. D.* An N,N’-diaryl urea based conjugated polymer model system. Tetrahedron Lett. 2004, 45, 3229-3232.
  70. Shimizu, L. S.*; Hughes, A. D.; Smith, M. D.; Davis, M. J.; Zhang, P.; zur Loye, H. –C.; Shimizu, K. D. Self-assembled nanotubes that reversibly bind acetic acid guests. J. Am. Chem. Soc. 2003, 125, 14972-3.
  71. Shimizu, L. S.*; Smith, M. D. Hughes, A. D.; Shimizu, K. D. Self-assembly of a bis-urea macrocycle into a columnar nanotube. Chem. Commun. 2001, 1592-1593.
  72. Renold, P.; Tsang, K. Y.; Shimizu, L. S.; Kemp, D. S.* For short alanine-lysine peptides the helical propensities of lysine residues (s Values) are strongly temperature dependent. J. Am. Chem. Soc. 1996, 118, 12234-12235.
  73. Stanley, J. A.*; Dakin, S.; Szabo L. (Shimizu); Posaw, L.; Lee, C.; Hou, W. M. A convenient preparation of trans-3,4-dephenyl- and trans, trans-2,3,4-triphenylvalerolactones. Org. Prep. Proc. Int. 1991, 23, 193-195.

SERVICE (selected examples since 2010)

  • Councilor, SC-American Chemical Society, local section 2020-2025.
  • Member, International Symposium on Macrocyclic and Supramolecular Chemistry (ISMSC) International Committee, 2023-present.
  • Member, Editorial Board of the Journal of Photochemistry and Photobiology A: Chemistry
  • Member, Editorial Board of Supramolecular Chemistry
  • Past Chair, SC-American Chemical Society, local section 2019.
  • Chair, SC-American Chemical Society, local section 2018.
  • Chair-Elect, SC-American Chemical Society, local section 2017.
  • Co-Organizer, ORGN Symposium on Functional Organic Assemblies Fall 2020 ACS National Meeting.
  • Co-Organizer, Inter-American Photochemical Society Winter Meeting, Jan 2-5, 2014 Sarasota FL.
  • Director, University of SC Department of Chemistry & Biochemistry Outreach Program, 2000-present.
  • Elected Member, Advisory Board for the Inter-American Photochemical Society (I-APS), 2012 –2016.
  • Organizer, Organic Division Summer Seminar Series 2005-present.
  • Co-Facilitator, UofSC College of Arts & Sciences Mid-Career Faculty Development Program, 2020-2022.
  • Co-Chair, Provost’s Advisory Committee on Women’s Issues (PACWI), 2014 – 2016.
  • Member, USC’s Garnet Apple Award Selection Committee, 2019-2020.
  • Member, USC’s Mungo Undergraduate Award Selection Committee, 2017, 2019.
  • Member, Provost’s Advisory Committee on Women’s Issues (PACWI), 2013 – 2016.
  • Member, USC Faculty Senate, 2013-2016.
  • Co-Organizer and Moderator, Graduate Panel on Transitions to Industry, April 20, 2015.
  • Member, Focus on Learning, Innovation, and Pedagogy Community at USC 2014-2017.
  • Research Mentor, Project Seed Program at USC, 2011-2014, 2017, 2018
  • Chair, Graduate Recruiting Committee, Chemistry and Biochemistry, 2019-2021.