Linda Shimizu

 

Professor of Chemistry

University of South Carolina

Department of Chemistry and Biochemistry

Columbia, SC 29208

RESEARCH INTERESTS

  • Organic, Supramolecular Chemistry, Out of Equilibrium Systems, Nanomaterials, Bioorganic, Organic Photochemistry, Crystal Engineering

PROFESSIONAL EXPERIENCE

  • Professor, Chemistry and Biochemistry, University of South Carolina, Columbia SC, 2016 – present.
  • Fulbright US Scholar, University of Vienna Visiting Professor of Science, March 1, 2018 – June 30, 2018.
  • Associate Professor, Chemistry and Biochemistry, University of South Carolina, Columbia SC, 2011 – 2015.
  • Visiting Professor, Center for Nanosystems Chemistry and the Institute of Organic Chemistry, University of Würzburg, Germany, Summer 2015.
  • Assistant Professor, Chemistry and Biochemistry, University of South Carolina, Columbia SC, 2005 – 2011.
  • Research Assistant Professor (part-time), University of South Carolina, Columbia SC, June 1998-Jan 1999, 2000-2001, 2003-2005.
  • Consultant Abt Associates Inc. 2003 –2004

 EDUCATION

  • NIH Post-doctoral Fellow, Massachusetts Institute of Technology, Cambridge, MA  1997- 1998,
  • Ph.D. in Organic Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 1997
  • Dissertation: “Synthesis and Conformation of Peptides:  I. Stability of Short Templated a-Helical Peptides.  II. New Templates for Intramolecular Acyl Transfer.”
  • BA in Chemistry and German Language and Literature, Magna Cum Laude, Wellesley College, MA, 1990.

HONORS AND AWARDS

  • Outstanding South Carolina Chemist, South Carolina Section of the ACS, 2024.
  • SC Governor’s Award for Scientific Awareness, 2021
  • Fulbright U.S. Scholar grant, 2017-2018
  • Michael J. Mungo Undergraduate Teaching Award, 2016
  • Editorial Board, Journal of Photochemistry and Photobiology A: Chemistry, 2014 – present
  • Editorial Board, Supramolecular Chemistry, 2014 – present
  • SC ACS Outreach Volunteers of the Year, 2014
  • ACS Women Chemists Committee 2013 Rising Star Award
  • USC Breakthrough Rising Star, 2011.

PUBLICATIONS / BOOK CHAPTERS    

  1. Islam, Md. Faizul; Wijesekera, Gamage Isuri P.; Sindt, Ammon J.; Smith, Mark D.; Shimizu, Linda S.* Examination of Photoinduced Radicals in Two Crystal Forms of Triphenylamine Bis-Urea Macrocycles. CrystEngComm. 2024 DOI: 10.1039/D4CE00839A.
  2. Wijesekera, Gamage Isuri P.; Gbadamosi, Fahidat A.; Hossain, Muhammad Saddam; Patra, Abhilash; Sutton, Christopher A.*; Shimizu Linda S.* Understanding the Key Factors for Photoinduced Radical Generation in Crystalline Triphenylamines Using Experiment and Machine Learning.  J. Phys. Chem. C 2024, https://pubs.acs.org/doi/10.1021/acs.jpcc.4c03579.
  3. Prakash, Rahul; Esmaeili, Mohsen; Gbadamosi, Fahidat, Pellechia, Perry J.; Sadati, Monirosadat; Shimizu, Linda S.* Supramolecular Gelation of Triphenylamine Bis-Urea Macrocycles in Toluene.  Macromolecules 2024, 57, 1312-1318.  https://pubs.acs.org/doi/10.1021/acs.macromol.3c02402.
  4. Rubert, Llorenc; Islam, Md Faizul; Greytak, Andrew B.; Prakash, Rahul; Smith, Mark, D.; Gomila, Rosa Maria; Frontera, Antonio; Shimizu, Linda S.*; Soberats, Bartolome* Two-Dimensional Supramolecular Polymerization of a Bis-Urea Macrocycle into a Brick-Like Hydrogen-Bonded Network. Angew. Chem. Int. Ed.  2023, 62, e202312223. https://onlinelibrary.wiley.com/doi/abs/10.1002/ange.202312223 
  5. Prakash, Rahul; Islam, Md Faizul; Kothalawala, Rajeen Madawa; Hossain, Mohammad Saddam; Smith, Mark D.; Shimizu, Linda S.* Cooperative Supramolecular Polymerization of Triphenylamine bis-Urea Macrocycles. Chem-Eur. J. 2023, 29, e202300698. https://doi.org/10.1002/chem.202300698
  6. Selvanesan, Benson Chellakkan; Varghese, Sheelu; Andrys, Justyna; Hernandez, Ricardo Arriaza; Prakash, Rahul; Tiwari, Purushottam; Hupalo, Daniel; Gusev, Yuriy; Patel, Meghja Nitin; Contente, Sara; Sanda, Miloslav; Uren, Aykut; Wilkerson, Matthew D.; Dalgard, Clifton Lee; Shimizu, Linda S.; Chruszcz, Maksymilian; Borowski, Tomasz; Upadhyay, Geeta* LY6K signaling to Aurora Kinase promotes advancement of the cell cycle and the growth of cancer cells, which is inhibited by LY6K-NSC243928 interaction. Cancer Lett. 2023, (* from USUHS) 10.1016/j.canlet.2023.216094
  7. Busschaert, Nathalie*; Garcia-Lopez, Victor; Ke, Chenfeng; McGuirk, C. Michael; Shimizu, Linda S.; Gerthoffer, Margaret C.; Bhattacharjee, Nabarupa  NASC: bringing together Supramolecular chemists from across North America, Supramol. Chem. 2023, 10.1080/10610278.2023.2178724
  8. Prakash, Rahul; Goodlett, Dustin W.; Gbadamosi, Fahidat; Hernandez, Ricardo A.; Chruszcz, Maksymilian; Borowski, Tomasz; Shimizu, Linda S.; Upadhyay, Geeta* Development of fluorophore labeled or biotinylated anticancer small molecule NSC243928. Bioorg. Med. Chem. 2023, 79, 117171. https://doi.org/10.1016/j.bmc.2023.117171  *From Uniformed Services University of Health Sciences
  9. Islam, Md. Faizul; Adame-Ramirez, Emely; Williams, Eric; Kittikhunnatham, Preecha; Wijesekera, Andrew; Zhang, Siteng; Ge, Ting; Stefik, Morgan; Smith, Mark, D.; Pellechia, Perry J.; Greytak, Andrew B.; Shimizu, Linda S.* Inclusion polymerization of pyrrole and ethylenedioxythiophene in assembled triphenylamine bis-urea macrocycles, Macromolecules, 2022, 55, 11013-11022. https://doi.org/10.1021/acs.macromol.2c02042
  10. Hossain, M. S.; Ahmed, F., Karakalos, S. G.; Smith, Mark, D.; Pant, N.; Garashchuk, S.; Greytak, A. B.; Docampo, P.; Shimizu, L. S.* Structure Property Investigations in Urea Tethered Iodinated Triphenylamines.
    Phys. Chem. Chem. Phys. 2022, 24, 18729-18737. https://doi.org/10.1039/D2CP01856J
  11. Oluwatoba, D. S.; Islam, M. F.; Som, B.; Sindt, A. J.; Smith, M. D.; Shimizu, L. S.; Do, T. D.* Evaluating the Effects of Metal Adduction and Charge Isomerism on Ion-Mobility Measurements using m-Xylene Macrocycles as Models. J. Am. Soc. Mass Spec. 2022, 33, 5, 840-850. https://doi.org/10.1021/jasms.2c00033.
  12. Helmers, I.; Hossain, M. S.; Bäumer, Nils; Wesarg, P.; Soberats, B.; Shimizu, L. S.*; Fernández, G.* Anti-cooperative Self-Assembly with Maintained Emission Regulated by Conformational and Steric Effects. Angew. Chem. Int. Ed. 2022,134, e202200390. DOI:10.1002/anie.202200390. Angew. Chem. 2022, 134, e202200390, DOI: 10.1002/ange.202200390.
  13. Daneshian, L.; Renggli, I.; Hanaway, R.; Offermann, L. R.; Schlacter, C. R.; Hernandez, R. A.; Henry, S.; Prakash, R.; Wybouw, N.; Dermauw, W.; Shimizu, L. S.; Van Leeuwen, T.; Makris, R.; Grbic. V.; Gribic, M.; Chruszcz, M.* Structural and Functional Characterization of Beta-Cyanoalanine Synthase from Tetranychus urticae. Insect Biochem. Molec. 2022, 142, 103722. https://doi.org/10.1016/j.ibmb.2022.103722
  14. Goodlett, R. L.; Sindt, A. J.; Islam, Md F.; Smith, M. D.; Shimizu, L. S.* Selective loading of xylene constitutional isomers in a self-assembled triphenylamine bis-urea macrocycle host. Cryst. Growth Des. 2022, 22, 1017-1023. DOI:10.1021/acs.cgd.1c00846.
  15. Islam, Md. F.; Sindt, A. J.; Hossain, M. S.; Ayare, P. J.; Smith, M. D.; Vannucci, A. K.; Garashchuk, S.; Shimizu, L. S.* Assembled triphenylamine bis-urea macrocycles: Exploring photodriven electron transfer from host to guests. Phys. Chem. Chem. Phys. 2021, 23, 23952-23960. DOI:10.1039/D1CP03000K.
  16. Hossain, M. S.; Sindt, A. J.; Goodlett, R. L.; Shields, D.; O’Connor, C. J.; Antevska, A.; Krakalos, S. G.; Smith, M. D.; Garashchuk, S.; Do, T. D.; Gudmundsdottir, A.; Shimizu, L. S.* Effects of self-assembly on the photogeneration of radical cations in halogenated triphenylamines. J. Phys. Chem. C 2021, 125, 19991-20002. DOI:10.1021/acs.jpcc.1c04933
  17. Som, B.; Smith, M. D.; Shimizu, L. S.* Multi-dimensional copper(I) and silver(I) coordination polymers assembled with a pyridyl bis-urea macrocyclic ligand. Polyhedron 2021, 201, 115170. DOI:10.1016/j.poly.2021.115170.
  18. Goodlett, R. L.; Sindt, A. J.; Hossain, M. S.; Merugu, R.; Smith, M. D.; Garashchuk, S.; Gudmundsdottir, A. D.; Shimizu, L. S.* From incident light to persistent and regenerable radicals of urea-assembled benzophenone frameworks: A structural investigation. J. Phys. Chem. A 2021, 126, 1336-1344. DOI:10.1021/acs.jpca.0c08953.
  19. Pote, S.; Kachhap, S.; Mank, N. J.; Daneshian, L.; Klapper, V.; Pye, S.; Arnett, A. K.; Shimizu, L. S.; Borowski, T.; Chruszcz, M.* Comparative structural and mechanistic studies of 4-hydroxy-tetrahydrodipicolinate reductases from Mycobacterium tuberculosis and Vibrio vulnificus. Biochimica et Biophysica Acta – General subjects 2021, 1865, 129750, DOI:1016/j.bbagen.2020.129750.
  20. Link, B. A.; Sindt, A. J.; Shimizu, L. S.; Do, T. D.* Selective host-guest chemistry: Self-assembly and conformational preferences of m-xylene macrocycles probed by ion-mobility mass spectrometry, Phy. Chem. Chem. Phys, 2020, 22, 9290-9300. *From University of Tennessee, Knoxville.  DOI:10.1039/C9CP06938K.
  21. Benti, S.; Tiwari, P. B.; Goodlett, D. W.; Daneshian, L.; Kern, G. B.; Smith, M. D.; Uren, A.; Chruszcz, M.; Shimizu, L. S.; Upadhyay, G.* Small molecule binds with Lymphocyte antigen 6K to induce cancer cell death. Cancers 2020, 12, 509- DOI:3390/cancers12020509. *From Uniformed Services University of Health Sciences
  22. Sindt, A. J.; DeHaven, B. A.; Goodlett, R. L.; Hartel, J. O.; Ayare, P. J.; Du, Y.; Smith, M. D.; Brugh, A. M.; Forbes, M. D. E.; Bowers, C. R.; Vannucci, A. K.; Shimizu, L. S.* Guest inclusion modulates concentration and persistence of photogenerated radicals in assembled triphenylamine macrocycles. J. Am. Chem. Soc. 2020, 142, 502-511. DOI: 10.1021/jacs.9b11518
  23. DeHaven, B. A.; Chen, A. L.; Shimizu, E. A.; Smith, M. D.; Shimizu, L. S.* Interplay between hydrogen and halogen bonding in co-crystals of dipyridylmethyl oxalamides and tetrafluorodiidodbenzenes. Cryst. Growth Des. 2019, 19, 5776-5783, doi: 10.1021/acs.cgd.9b00796.
  24. DeHaven, B. A.; Liberatore, H. K.; Greer, A.; Richardson, S. D.; Shimizu, L. S.* Probing the formation of reactive oxygen species by a porous self-assembled benzophenone bis-urea host. ACS Omega 2019, 4, 8290-8298, doi: 10.1021/acsomega.9b00831.
  25. Sindt, A. J.; Smith, M. D.; Berens, S.; Vasenkov, S.; Bowers, C. R.; Shimizu, L. S.* Single-crystal-to-single-crystal guest exchange in columnar assembled bromotriphenylamine bis-urea macrocycles. Chem. Commun. 2019, 55, 5619-5622, doi: 10.1039/C9CC01725A.
  26. Sindt, A. J.; DeHaven, B. A.; McEachern, D. F.; Dissanayake, M. M.; Smith, M. D.; Vannucci, A. K.; Shimizu, L. S.* UV-irradiation of self-assembled triphenylamines affords persistent and regenerable radicals. Chem Sci. 2019, 10, 2670-2677 doi: 10.1039/C8SC04607G.
  27. DeHaven, B. A.; Goodlett, R. L.; Sindt, A. J.; Noll, N.; DeVetta, M.; Smith, M. D.; Martina, C. R.; González, L.; Shimizu, L. S.* Enhancing the stability of photogenerated benzophenone triplet radical pairs through supramolecular assembly. J. Am. Chem. Soc.2018, 140, 13064-13070, doi 10/1021/jacs.8b08501.
  28. Sindt, A. J.; Smith, M. D.; Pellechia, P. J.; Shimizu, L. S.* Thioureas and Squaramides: A Comparison with Ureas as Assembly Directing Motifs for m-xylene macrocycles. Cryst. Growth Des. 2018, 18, 1602-1612, doi:10.1021/acs.cgd.7b01558.
  29. Som, B.; Shue, J.; Smith, M. D.; Shimizu, L. S.* Temperature induced polymorphism of salt co-crystal solvates from a Pyridyl Bis-urea Macrocycle with Naphthalene-1,5-disulfonic acid.J. Chem. Crystallogr., 2018, C74, 75-81, doi: 10.1107/S2053229617017600.
  30. DeHaven, B. A.; Chen, A. L.; Shimizu, E. A.; Salpage, S. R.; Smith, M. D.; Shimizu, L. S.* Synergistic Effects of Hydrogen and Halogen Bonding in Co-Crystals of Dipyridyl Ureas and Diiodotetrafluoro-benzenes. Supramol. Chem. 2018, 30, 315-327, doi: 10.1080/10610278.2017.136480.
  31. Kittikhunnatham, P.; Som, B.; Rassolov, V.; Stolte, M.; Würthner, F.; Shimizu, L. S. Greytak, A. B.* Fluorescence Polarization Measurements to Probe Alignment of a Bithiophene Dye in 1D channels of Self-Assembled Bis-Urea Macrocycle Crystals. J. Phys. Chem. C. 2017, 121, 18102-18109. doi: 10.1021/acs.jpcc.7b07136.
  32. DeHaven, B. A.; Tokarski, J. T.; Korous, A. A.; Mentink-Vigier, F.; Makris, T. M.; Brugh, A. M.; Forbes, M. D. E.; van Tol, J.; Bowers, C. R.; Shimizu, L. S.* Endogenous radicals of self-assembled benzophenone bis-urea macrocycles: characterization and application as a polarizing agent for solid-state DNP MAS NMR spectroscopy. Chem-Eur J. 2017, 23, 8315-8319, doi: 1002/chem.201701705.
  33. Som, B.; Salpage, S. R.; Son, J.-O.; Gu, B.; Karakalos, S. G.; Smith, M. D.; Shimizu, L. S.* Pillars of assembled pyridyl bis-urea macrocycles: A robust synthon to organize diiodotetrafluorobenzenes. CrystEngComm, 2017, 19, 484-491, doi 1039/C6CE02392D.
  34. Salpage, S. R.; Xu, Y.; Som, B.; Sindt, A. J.; Smith, M. D.; Shimizu, L. S.* Pyridyl-phenylethynylene Bis-Urea Macrocycles: Self-Assembly and Utility as a Nanoreactor for the Selective Photoreaction of Isoprene. RSC Advances 2016, 6, 98350-98355, doi: 1039/C6RA18681E.
  35. Salpage, S. R.; Paul, A.; Som, B.; Banerjee, T.; Hanson, K.; Smith, M. D.; Vannucci, A. K.; Shimizu, L. S.* Structure, electrochemistry and photophysical properties of an exo diruthenium complex using a macrocyclic bridging ligand and its application as a photosensitizer. Dalton Trans. 2016, 45, 9601-9607, doi: 1039/C6DT01377E.
  36. Salpage, S. R.; Smith, M. D.; Shimizu, L. S.* Crystal Structures and Hirshfeld Surface Analyses of 6-Substituted Chromones. J. Chem. Crystallogr. 2016, 46, 170-180, doi: 10.1007/s10870-016-0642-2.
  37. Salpage, S. R.; Donevant, L. S.; Smith, M. D.; Bick, A.; Shimizu, L. S.* Modulating the Reactivity of Chromone and Its Derivatives through Encapsulation in a Self-Assembled Phenylethynylene Bis-Urea Host. J. Photochem. Photobio. A 2016, 315, 14-24, doi: 10.1016/j.jphotochem.2015.09.003.
  38. Bowers, C. R.*; Dvoyahshin, M.; Salpage, S. R.; Akel, C.; Bhase, H.; Geer, M. F.; Shimizu, L. S.* Squeezing Xenon into Phenylether bis-Urea Nanochannels. Can. J. Chem. 2015, 93, 1031-1034, doi: dx.doi.org/10.1139/cjc-2015-0152.
  39. Bowers, C. R.*; Dvoyahshin, M.; Salpage, S. R.; Akel, C.; Bhase, H.; Geer, M. F.; Shimizu, L. S.* Crystalline bis-Urea Nanochannel Architectures Tailored for Single-File Diffusion Studies. ACS Nano 2015, 9, 6343-6353.
  40. Dawn, S.; Salpage, S. R.; Koscher, B. A.; Wibowo, A. C.; Pellechia, P. J.; Shimizu, L. S.* Applications of a bis-urea phenylethynylene self-assembled nanoreactor for [2+2] photodimerizations. J. Phys. Chem. A. 2014, 118, 10563-10574.
  41. Shimizu, L. S.*; Salpage, S. R.; Korous A. F. Functional Materials from Self-Assembled bis-Urea Macrocycles. Acc. Chem. Res. 2014, 47, 2116-2127.
  42. Xu, W. L.; Smith, M. D.; Krause, J. A.; Greytak, A. B.; Ma, S.; Read, C. M.; Shimizu, L. S.* Single Crystal to Single Crystal Polymerization of a Self-Assembled Diacetylene Macrocycle Affords Columnar Polydiacetylenes. Cryst. Grow. Des. 2014, 14, 993-1002.
  43. Xu, Y.; Xu, W. L.; Smith, M. D.; Shimizu, L. S.* Self-assembly and Ring-opening Metathesis Polymerization of a Bifunctional Carbonate Stilbene Macrocycle. RSC Advances, 2014, 4, 1675-1682.
  44. Geer, M. F.; Mazzuca, J.; Smith, M. D.; Shimizu, L. S.* Strong, short halogen bonds in co-crystals of pyridyl bis-urea macrocycles with iodo-perfluorocarbons. Cryst. Eng. Comm. 2013, 15, 9923-9929.
  45. Caricato, M.; Leza, N.; Roy, K.; Dondi, D.; Gattuso, G.; Shimizu, L. S.; Vander Griend D. A.; Pasini, D.* A Chiroptical Probe for Sensing Metal Ions in Physiological Conditions. J. Org. Chem. 2013, 6078-6083.
  46. Geer, M. F.; Walla, M. D.; Solntsev, K. M.; Strassert, C. A.; Shimizu, L. S.* Self-assembled benzophenone bis-urea macrocycles facilitate selective oxidations by singlet oxygen. J. Org. Chem. 2013, 78, 5568-5578.
  47. Roy, K.; Wibowo, A. C.; Pellechia, P. J.; Ma, S.; Geer, M. F.; Shimizu, L. S.* Absorption of hydrogen bond donors by pyridyl bis-urea crystals. Chem. Mater. 2012, 24, 4773-4781.
  48. Dawn, S.; Salpage, S. R.; Smith, M. D.; Sharma, S. K.; Shimizu, L. S.* A trinuclear silver coordination polymer from a bipyridine bis-urea macrocyclic ligand and silver triflate. Chem. Commun. 2012, 15, 88-92.
  49. Geer, M. F.; Shimizu, L. S.* “Self-Assembly and Self-Organization” Chapter in Volume 1: Concepts in Supramolecular Chemistry From Molecules to Nanomaterials Series Editors: Philip A. Gale, Jonathan, W. Steed, John Wiley & Sons, Ltd. United Kingdom, 2012, 1, 167-180.
  50. Xu, Y.; Shimizu, L. S.* “Urea Capsules” In The Encyclopedia of Supramolecular Chemistry; Atwood, J. L.; Steed, J. W.; Wallace, K. J., Ed.; Taylor and Francis, CDC Press, 2012, doi 1081/E-ESMC-120048280.
  51. Dawn, S.; Dewal, M. B.; Sobransingh, D.; Paderes, M. C.; Wibowo, A. C.; Krause, J. A.; Smith, M. D.; Pellechia, P. J.; Shimizu, L. S.* Porous crystals from self-assembled phenylethynylene bis-urea macrocycles facilitate the selective photodimerization of coumarin. J. Am. Chem. Soc. 2011, 133, 7025-7032.
  52. Roy, K.; Smith, M. D.; Shimizu, L. S.* 1D coordination network formed by a cadmium based pyridyl urea helical monomer. Inorg. Chim. Acta 2011, 376, 598-604.
  53. Geer, M. F.; Smith, M. D.; Shimizu, L. S.* A bis-urea naphthalene macrocycle displaying two crystal structures with parallel ureas. Cryst. Eng. Comm. 2011, 13, 3665-3669.
  54. Roy, K.; Wang, C.; Smith, M. D.; Dewal, M. B.; Wibowo, A. C.; Brown, J. C.; Ma, S.; Shimizu, L. S.* Guest induced transformations of assembled pyridyl bis-urea Chem. Commun. 2011, 47, 277-279.
  55. Roy, K.; Wang, C.; Smith, M. D.; Pellechia, P. J.; Shimizu, L. S.* Alkali metal ions as probes of structure and recognition properties of macrocyclic pyridyl urea hosts. J.Org. Chem. 2010, 75, 5453-5460, Featured Article.
  56. Xu, Y.; Smith, M. D.; Geer, M. F.; Pellechia, P. J.; Brown, J. C.; Wibowo, A. C.; Shimizu, L. S.* Thermal reaction of a columnar assembled diacetylene macrocycle. J. Am. Chem. Soc. 2010, 132, 5334-5335. Highlighted by Synfacts.
  57. Tian, L.; Wang, C.; Dawn, S.; Smith, M. D.; Krause, J. A.; Shimizu, L. S.* Macrocycles with switchable exo/endo metal binding sites. J. Am. Chem. Soc. 2009, 131, 17620-17629.
  58. Yang, J.; Dewal, M. B.; Sobransingh, D.; Xu, Y.; Smith, M. D.; Shimizu, L. S.* An examination of the structural features that favor the columnar self-assembly of bis-urea macrocycles. J. Org. Chem. 2009, 74, 102-110.
  59. Xu, Y.; Smith, M. D.; Krause, J.; Shimizu, L. S.* Control of the intramolecular [2+2] photocycloaddition of a bis-stilbene macrocycle. J. Org. Chem. 2009, 74, 4874-4877.
  60. Dewal, M. B.; Xu, Y.; Yang, J.; Mohammed, F.; Smith, M. D.; Shimizu, L. S.* Manipulating the cavity of a porous material changes the photoreactivity of included guests. Chem. Commun. 2008, 3909-3911. Highlighted by Nature Chem., July 11, 2008, doi:10.1038/nchem.36.
  61. Yang, J.; Dewal, M. B.; Profeta, S.; Smith, M. D.; Li, Y.; Shimizu, L. S.* Origins of selectivity for the [2+2] cycloaddition of alpha, beta-unsaturated ketones within a porous self-assembled organic framework. J. Am. Chem. Soc. 2008, 130, 612-621.
  62. Sobransingh, D.; Dewal, M. B.; Hiller, J.; Smith, M. D.; Shimizu, L. S.* Inclusion of electrochemically active guests by novel oxacalixarene hosts. New. J. Chem. 2008, 32, 24-27.
  63. Shimizu, L. S.* Perspectives in main-chain hydrogen bonded supramolecular polymers. Polymers International 2007, 56, 444-452.
  64. Dewal, M. B.; Lufaso, M. W.; Hughes, A. D.; Samuel, S. A.; Pellechia, P.; Shimizu L. S.* Absorption properties of a porous organic crystalline apohost formed by a self-assembled bis-urea macrocycle. Chem.  Mater. 2006, 18, 4855-4864.
  65. Yang, J.; Dewal, M. B.; Shimizu, L. S.* Self-assembling bis-urea macrocycles used as an organic zeolite for a highly stereoselective photodimerization of 2-cyclohexenone. J. Am. Chem. Soc. 2006, 128, 8122-8123.
  66. Shimizu, L. S.*; Smith, M. D.; Hughes, A. D.; Samuel, S.; Ciurtin-Smith, D. Assembled tubular structures from bis-urea macrocycles. Supramolecular Chem. 2005, 17, 27-30.
  67. Ricks, H. L.; Shimizu, L. S.; Smith, M. D.; Bunz, U. H. F.; Shimizu, K. D.* An N,N’-diaryl urea based conjugated polymer model system. Tetrahedron Lett. 2004, 45, 3229-3232.
  68. Shimizu, L. S.*; Hughes, A. D.; Smith, M. D.; Davis, M. J.; Zhang, P.; zur Loye, H. –C.; Shimizu, K. D. Self-assembled nanotubes that reversibly bind acetic acid guests. J. Am. Chem. Soc. 2003, 125, 14972-3.
  69. Shimizu, L. S.*; Smith, M. D. Hughes, A. D.; Shimizu, K. D. Self-assembly of a bis-urea macrocycle into a columnar nanotube. Chem. Commun. 2001, 1592-1593.
  70. Renold, P.; Tsang, K. Y.; Shimizu, L. S.; Kemp, D. S.* For short alanine-lysine peptides the helical propensities of lysine residues (s Values) are strongly temperature dependent. J. Am. Chem. Soc. 1996, 118, 12234-12235.
  71. Stanley, J. A.*; Dakin, S.; Szabo L. (Shimizu); Posaw, L.; Lee, C.; Hou, W. M. A convenient preparation of trans-3,4-dephenyl- and trans, trans-2,3,4-triphenylvalerolactones. Org. Prep. Proc. Int. 1991, 23, 193-195.

SERVICE (selected examples since 2010)

  • Councilor, SC-American Chemical Society, local section 2020-2025.
  • Member, International Symposium on Macrocyclic and Supramolecular Chemistry (ISMSC) International Committee, 2023-present.
  • Member, Editorial Board of the Journal of Photochemistry and Photobiology A: Chemistry
  • Member, Editorial Board of Supramolecular Chemistry
  • Past Chair, SC-American Chemical Society, local section 2019.
  • Chair, SC-American Chemical Society, local section 2018.
  • Chair-Elect, SC-American Chemical Society, local section 2017.
  • Co-Organizer, ORGN Symposium on Functional Organic Assemblies Fall 2020 ACS National Meeting.
  • Co-Organizer, Inter-American Photochemical Society Winter Meeting, Jan 2-5, 2014 Sarasota FL.
  • Director, University of SC Department of Chemistry & Biochemistry Outreach Program, 2000-present.
  • Elected Member, Advisory Board for the Inter-American Photochemical Society (I-APS), 2012 –2016.
  • Organizer, Organic Division Summer Seminar Series 2005-present.
  • Co-Facilitator, UofSC College of Arts & Sciences Mid-Career Faculty Development Program, 2020-2022.
  • Co-Chair, Provost’s Advisory Committee on Women’s Issues (PACWI), 2014 – 2016.
  • Member, USC’s Diversity and Inclusion Advisory Committee, 2016 – 2018.
  • Member, USC’s Garnet Apple Award Selection Committee, 2019-2020.
  • Member, USC’s Mungo Undergraduate Award Selection Committee, 2017, 2019.
  • Member, Provost’s Advisory Committee on Women’s Issues (PACWI), 2013 – 2016.
  • Member, USC Faculty Senate, 2013-2016.
  • Member, Faculty Committee on Instructional Development, 2011-2014.
  • Co-Organizer and Moderator, Graduate Panel on Transitions to Industry, April 20, 2015.
  • Member, Focus on Learning, Innovation, and Pedagogy Community at USC 2014-2017.
  • Research Mentor, Project Seed Program at USC, 2011-2014, 2017, 2018
  • Member, I-APS Awards Committee, 2012-2016.
  • Chair, Graduate Recruiting Committee, Chemistry and Biochemistry, 2019-2021.
  • Chair, GAANN Advisory Committee, Chemistry and Biochemistry, 2012-2016.